There are greater problems than a guide rod for putting a 10MM barrel into a G-21 slide.
The 10 mm will not work satisfactorily in a G-21 slide. I tried a 10 MM barrel in a Tactical length G-21 barrel from Lone Wolf. It was totally unreliable, mainly ejection problems. They eventually told me that it wouldn't work and replaced the 10 MM barrel that they had cut down with a 5.15 " G 21 barrel. They said the 10 MM casing is too big for the G-21 ejection port to allow the gun to recycle reliably.
The 10 mm will not work satisfactorily in a G-21 slide. I tried a 10 MM barrel in a Tactical length G-21 barrel from Lone Wolf. It was totally unreliable, mainly ejection problems. They eventually told me that it wouldn't work and replaced the 10 MM barrel that they had cut down with a 5.15 " G 21 barrel. They said the 10 MM casing is too big for the G-21 ejection port to allow the gun to recycle reliably.